High-power test results of a 3 GHz single-cell cavity

Compact, reliable and little consuming accelerators are required for the treatment of tumours with ions. TERA proposes the "cyclinac", composed of a high-frequency, fast-cycling linac which boosts the energy of the particles previously accelerated in a cyclotron. The dimensions of the linac can be reduced if high gradients are used. TERA initiated a high-gradient test program to understand the operational limit of such structures. The program foresees the design, prototyping and high-power test of several high-gradient structures operating at 3 and 5.7 GHz. The high-power tests of the 3 GHz single-cell cavity were completed in Winter 2012. The maximum BDR threshold measured for Emax of 170 MV/m and RF pulses of 2.5 \mu s was 3 x 10-6 bpp/m

Limits on the low energy antinucleon-nucleus annihilations from the Heisenberg principle

We show that the quantum uncertainty principle puts some limits on the effectiveness of the antinucleon-nucleus annihilation at very low energies. This is caused by the fact that the realization a very effective short-distance reaction process implies information on the relative distance of the reacting particles. Some quantitative predictions are possible on this ground, including the approximate A-independence of antinucleon-nucleus annihilation rates.Comment: 10 pages, no figure

Dental implants with anti-biofilm properties: A pilot study for developing a new sericin-based coating

Aim: several strategies have been tested in recent years to prevent bacterial colonization of dental implants. Sericin, one of the two main silk proteins, possesses relevant biological activities and also literature reports about its potential antibacterial properties, but results are discordant and not yet definitive. The aim of this study was to evaluate the effectiveness of different experimental protocols in order to obtain a sericin-based coating on medical grade titanium (Ti) able to reduce microbial adhesion to the dental implant surface. Materials and Methods: different strategies for covalent bonding of sericin to Ti were pursued throughout a multi-step procedure on Ti-6Al-4V disks. The surface of grade 5 Ti was initially immersed in NaOH solution to obtain the exposure of functional -OH groups. Two different silanization strategies were then tested using aminopropyltriethoxysilane (APTES). Eventually, the bonding between silanized Ti-6Al-4V and sericin was obtained with two different crosslinking processes: glutaraldehyde (GLU) or carbodiimide/N-Hydroxy-succinimide (EDC/NHS). Micro-morphological and compositional analyses were performed on the samples at each intermediate step to assess the most effective coating strategy able to optimize the silanization and bioconjugation processes. Microbiological tests on the coated Ti-6Al-4V disks were conducted in vitro using a standard biofilm producer strain of Staphylococcus aureus (ATCC 6538) to quantify the inhibition of microbial biofilm formation (anti-biofilm efficacy) at 24 hours. Results: both silanization techniques resulted in a significant increase of silicon (Si) on the Ti-6Al-4V surfaces etched with NaOH. Differences were found between GLU and EDC/NHS bioconjugation strategies in terms of composition, surface micro-morphology and anti-biofilm efficacy. Ti-6Al-4V samples coated with GLU-bound sericin after silanization obtained via vapor phase deposition proved that this technique is the most convenient and effective coating strategy, resulting in a bacterial inhibition of about 53% in respect to the uncoated Ti-6Al-4V disks. Conclusions: The coating with glutaraldehyde-bound sericin after silanization in the vapor phase showed promising bacterial inhibition values with a significant reduction of S. aureus biofilm. Further studies including higher number of replicates and more peri-implant-relevant microorganisms are needed to evaluate the applicability of this experimental protocol to dental implants. View Full-Tex

Three Dimensional Annihilation Imaging of Antiprotons in a Penning Trap

We demonstrate three-dimensional annihilation imaging of antiprotons trapped in a Penning trap. Exploiting unusual feature of antiparticles, we investigate a previously unexplored regime in particle transport; the proximity of the trap wall. Particle loss on the wall, the final step of radial transport, is observed to be highly non-uniform, both radially and azimuthally. These observations have considerable implications for the production and detection of antihydrogen atoms.Comment: Invited Talk at NNP03, Workshop on Non-Neutral Plasmas, 200

First determination of the one-proton induced Non-Mesonic Weak Decay width of p-shell {\Lambda}-Hypernuclei

Previous studies of proton and neutron spectra from Non-Mesonic Weak Decay of eight Lambda-Hypernuclei (A = 5-16) have been revisited. New values of the ratio of the two-nucleon and the one-proton induced decay widths, Gamma_2N/Gamma_p, are obtained from single proton spectra, Gamma_2N/Gamma_p = 0.50 +/- 0.24, and from neutron and proton coincidence spectra, Gamma_2N/Gamma_p = 0.36 +/- 0.14stat +0.05sys -0.04sys , in full agreement with previously published ones. With these values, a method is developed to extract the one-proton induced decay width in units of the free Lambda decay width, Gamma_p/Gamma_Lambda, without resorting to Intra Nuclear Cascade models but by exploiting only experimental data, under the assumption of a linear dependence on A of the Final State Interaction contribution. This is the first systematic determination ever done and it agrees within the errors with recent theoretical calculations.Comment: 16 pages, 3 figures, 2 table

A practical guide to the simultaneous determination of protein structure and dynamics using metainference

Accurate protein structural ensembles can be determined with metainference, a Bayesian inference method that integrates experimental information with prior knowledge of the system and deals with all sources of uncertainty and errors as well as with system heterogeneity. Furthermore, metainference can be implemented using the metadynamics approach, which enables the computational study of complex biological systems requiring extensive conformational sampling. In this chapter, we provide a step-by-step guide to perform and analyse metadynamic metainference simulations using the ISDB module of the open-source PLUMED library, as well as a series of practical tips to avoid common mistakes. Specifically, we will guide the reader in the process of learning how to model the structural ensemble of a small disordered peptide by combining state-of-the-art molecular mechanics force fields with nuclear magnetic resonance data, including chemical shifts, scalar couplings and residual dipolar couplings.Comment: 49 pages, 9 figure

Positron plasma diagnostics and temperature control for antihydrogen production

Production of antihydrogen atoms by mixing antiprotons with a cold, confined, positron plasma depends critically on parameters such as the plasma density and temperature. We discuss non-destructive measurements, based on a novel, real-time analysis of excited, low-order plasma modes, that provide comprehensive characterization of the positron plasma in the ATHENA antihydrogen apparatus. The plasma length, radius, density, and total particle number are obtained. Measurement and control of plasma temperature variations, and the application to antihydrogen production experiments are discussed.Comment: 5 pages, 4 figures, to be published in Phys. Rev. Let

ATHENA -- First Production of Cold Antihydrogen and Beyond

Atomic systems of antiparticles are the laboratories of choice for tests of CPT symmetry with antimatter. The ATHENA experiment was the first to report the production of copious amounts of cold antihydrogen in 2002. This article reviews some of the insights that have since been gained concerning the antihydrogen production process as well as the external and internal properties of the produced anti-atoms. Furthermore, the implications of those results on future prospects of symmetry tests with antimatter are discussed.Comment: Proc. of the Third Meeting on CPT and Lorentz Symmetry, Bloomington (Indiana), USA, August 2004, edited by V. A. Kostelecky (World Scientific, Singapore). 10 pages, 5 figures, 1 table. Author affiliations cor